Roadmap for investigating epigenome deregulation and environmental origins of cancer.
Identifieur interne : 000421 ( Main/Exploration ); précédent : 000420; suivant : 000422Roadmap for investigating epigenome deregulation and environmental origins of cancer.
Auteurs : Zdenko Herceg [France] ; Akram Ghantous [France] ; Christopher P. Wild [France] ; Athena Sklias [France] ; Lavinia Casati [Italie] ; Susan J. Duthie [Royaume-Uni] ; Rebecca Fry [États-Unis] ; Jean-Pierre Issa [États-Unis] ; Richard Kellermayer [États-Unis] ; Igor Koturbash [États-Unis] ; Yukata Kondo [Japon] ; Johanna Lepeule [France] ; Sheila C S. Lima [Brésil] ; Carmen J. Marsit [États-Unis] ; Vardhman Rakyan [Royaume-Uni] ; Richard Saffery [Australie] ; Jack A. Taylor [États-Unis] ; Andrew E. Teschendorff [Royaume-Uni] ; Toshikazu Ushijima [Japon] ; Paolo Vineis [Royaume-Uni] ; Cheryl Lyn Walker [États-Unis] ; Robert A. Waterland [États-Unis] ; Joe Wiemels [États-Unis] ; Srikant Ambatipudi [France] ; Davide Degli Esposti [France] ; Hector Hernandez-Vargas [France]Source :
- International journal of cancer [ 1097-0215 ] ; 2017.
Abstract
The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.
DOI: 10.1002/ijc.31014
PubMed: 28836271
Affiliations:
- Australie, Brésil, France, Italie, Japon, Royaume-Uni, États-Unis
- Angleterre, Arkansas, Auvergne-Rhône-Alpes, Californie, Caroline du Nord, Grand Londres, Géorgie (États-Unis), Lombardie, Pennsylvanie, Rhône-Alpes, Région de Kantō, Texas, Victoria (État), État de Rio de Janeiro
- Grenoble, Londres, Melbourne, Milan, Rio de Janeiro, Tokyo
- University College de Londres
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Lima</name><affiliation wicri:level="3"><nlm:affiliation>National Cancer Institute (INCA), Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>National Cancer Institute (INCA), Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Marsit, Carmen J" sort="Marsit, Carmen J" uniqKey="Marsit C" first="Carmen J" last="Marsit">Carmen J. Marsit</name><affiliation wicri:level="2"><nlm:affiliation>Emory University, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Rakyan, Vardhman" sort="Rakyan, Vardhman" uniqKey="Rakyan V" first="Vardhman" last="Rakyan">Vardhman Rakyan</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Genomics and Child Health, Blizard Institute, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Genomics and Child Health, Blizard Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="3"><nlm:affiliation>Murdoch Childrens Research Institute, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Childrens Research Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Taylor, Jack A" sort="Taylor, Jack A" uniqKey="Taylor J" first="Jack A" last="Taylor">Jack A. Taylor</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Health, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>National Institute of Health</wicri:cityArea></affiliation></author><author><name sortKey="Teschendorff, Andrew E" sort="Teschendorff, Andrew E" uniqKey="Teschendorff A" first="Andrew E" last="Teschendorff">Andrew E. Teschendorff</name><affiliation wicri:level="4"><nlm:affiliation>Statistical Cancer Genomics, UCL Cancer Institute & Dept. of Woman's Cancer, University College London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Statistical Cancer Genomics, UCL Cancer Institute & Dept. of Woman's Cancer, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Ushijima, Toshikazu" sort="Ushijima, Toshikazu" uniqKey="Ushijima T" first="Toshikazu" last="Ushijima">Toshikazu Ushijima</name><affiliation wicri:level="3"><nlm:affiliation>National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="3"><nlm:affiliation>MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Cheryl Lyn" sort="Walker, Cheryl Lyn" uniqKey="Walker C" first="Cheryl Lyn" last="Walker">Cheryl Lyn Walker</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular & Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular & Cellular Biology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Waterland, Robert A" sort="Waterland, Robert A" uniqKey="Waterland R" first="Robert A" last="Waterland">Robert A. Waterland</name><affiliation wicri:level="2"><nlm:affiliation>Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Wiemels, Joe" sort="Wiemels, Joe" uniqKey="Wiemels J" first="Joe" last="Wiemels">Joe Wiemels</name><affiliation wicri:level="2"><nlm:affiliation>UCSF School of Medicine, Epidemiology & Biostatistics, San Francisco, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>UCSF School of Medicine, Epidemiology & Biostatistics, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Ambatipudi, Srikant" sort="Ambatipudi, Srikant" uniqKey="Ambatipudi S" first="Srikant" last="Ambatipudi">Srikant Ambatipudi</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Degli Esposti, Davide" sort="Degli Esposti, Davide" uniqKey="Degli Esposti D" first="Davide" last="Degli Esposti">Davide Degli Esposti</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno 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of cancer.</title><author><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Ghantous, Akram" sort="Ghantous, Akram" uniqKey="Ghantous A" first="Akram" last="Ghantous">Akram Ghantous</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Wild, Christopher P" sort="Wild, Christopher P" uniqKey="Wild C" first="Christopher P" last="Wild">Christopher P. Wild</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Sklias, Athena" sort="Sklias, Athena" uniqKey="Sklias A" first="Athena" last="Sklias">Athena Sklias</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Casati, Lavinia" sort="Casati, Lavinia" uniqKey="Casati L" first="Lavinia" last="Casati">Lavinia Casati</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Duthie, Susan J" sort="Duthie, Susan J" uniqKey="Duthie S" first="Susan J" last="Duthie">Susan J. Duthie</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Life Sciences, The Robert Gordon University, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Pharmacy and Life Sciences, The Robert Gordon University, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Fry, Rebecca" sort="Fry, Rebecca" uniqKey="Fry R" first="Rebecca" last="Fry">Rebecca Fry</name><affiliation wicri:level="2"><nlm:affiliation>Gillings School of Global Public Health, UNC, Chapel Hill, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Gillings School of Global Public Health, UNC, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Issa, Jean Pierre" sort="Issa, Jean Pierre" uniqKey="Issa J" first="Jean-Pierre" last="Issa">Jean-Pierre Issa</name><affiliation wicri:level="2"><nlm:affiliation>Fels Institute for Cancer Research & Molecular Biology, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Fels Institute for Cancer Research & Molecular Biology, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Kellermayer, Richard" sort="Kellermayer, Richard" uniqKey="Kellermayer R" first="Richard" last="Kellermayer">Richard Kellermayer</name><affiliation wicri:level="2"><nlm:affiliation>Texas Children's Hospital, Baylor College of Medicine, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Texas Children's Hospital, Baylor College of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Koturbash, Igor" sort="Koturbash, Igor" uniqKey="Koturbash I" first="Igor" last="Koturbash">Igor Koturbash</name><affiliation wicri:level="2"><nlm:affiliation>University of Arkansas for Medical Sciences, AR.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arkansas</region></placeName><wicri:cityArea>University of Arkansas for Medical Sciences</wicri:cityArea></affiliation></author><author><name sortKey="Kondo, Yukata" sort="Kondo, Yukata" uniqKey="Kondo Y" first="Yukata" last="Kondo">Yukata Kondo</name><affiliation wicri:level="1"><nlm:affiliation>Aichi Cancer Center Research Institute, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Aichi Cancer Center Research Institute, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Lepeule, Johanna" sort="Lepeule, Johanna" uniqKey="Lepeule J" first="Johanna" last="Lepeule">Johanna Lepeule</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Albert Bonniot Institute, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Albert Bonniot Institute, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Lima, Sheila C S" sort="Lima, Sheila C S" uniqKey="Lima S" first="Sheila C S" last="Lima">Sheila C S. Lima</name><affiliation wicri:level="3"><nlm:affiliation>National Cancer Institute (INCA), Rio de Janeiro, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>National Cancer Institute (INCA), Rio de Janeiro</wicri:regionArea><placeName><settlement type="city">Rio de Janeiro</settlement><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Marsit, Carmen J" sort="Marsit, Carmen J" uniqKey="Marsit C" first="Carmen J" last="Marsit">Carmen J. Marsit</name><affiliation wicri:level="2"><nlm:affiliation>Emory University, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Emory University, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Rakyan, Vardhman" sort="Rakyan, Vardhman" uniqKey="Rakyan V" first="Vardhman" last="Rakyan">Vardhman Rakyan</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Genomics and Child Health, Blizard Institute, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Genomics and Child Health, Blizard Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name><affiliation wicri:level="3"><nlm:affiliation>Murdoch Childrens Research Institute, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Murdoch Childrens Research Institute, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Taylor, Jack A" sort="Taylor, Jack A" uniqKey="Taylor J" first="Jack A" last="Taylor">Jack A. Taylor</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Health, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>National Institute of Health</wicri:cityArea></affiliation></author><author><name sortKey="Teschendorff, Andrew E" sort="Teschendorff, Andrew E" uniqKey="Teschendorff A" first="Andrew E" last="Teschendorff">Andrew E. Teschendorff</name><affiliation wicri:level="4"><nlm:affiliation>Statistical Cancer Genomics, UCL Cancer Institute & Dept. of Woman's Cancer, University College London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Statistical Cancer Genomics, UCL Cancer Institute & Dept. of Woman's Cancer, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Ushijima, Toshikazu" sort="Ushijima, Toshikazu" uniqKey="Ushijima T" first="Toshikazu" last="Ushijima">Toshikazu Ushijima</name><affiliation wicri:level="3"><nlm:affiliation>National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="3"><nlm:affiliation>MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Walker, Cheryl Lyn" sort="Walker, Cheryl Lyn" uniqKey="Walker C" first="Cheryl Lyn" last="Walker">Cheryl Lyn Walker</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Molecular & Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Departments of Molecular & Cellular Biology and Medicine, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Waterland, Robert A" sort="Waterland, Robert A" uniqKey="Waterland R" first="Robert A" last="Waterland">Robert A. Waterland</name><affiliation wicri:level="2"><nlm:affiliation>Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Wiemels, Joe" sort="Wiemels, Joe" uniqKey="Wiemels J" first="Joe" last="Wiemels">Joe Wiemels</name><affiliation wicri:level="2"><nlm:affiliation>UCSF School of Medicine, Epidemiology & Biostatistics, San Francisco, CA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>UCSF School of Medicine, Epidemiology & Biostatistics, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Ambatipudi, Srikant" sort="Ambatipudi, Srikant" uniqKey="Ambatipudi S" first="Srikant" last="Ambatipudi">Srikant Ambatipudi</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Degli Esposti, Davide" sort="Degli Esposti, Davide" uniqKey="Degli Esposti D" first="Davide" last="Degli Esposti">Davide Degli Esposti</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, Lyon, 69008</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author></analytic><series><title level="j">International journal of cancer</title><idno type="eISSN">1097-0215</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Brésil</li><li>France</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Arkansas</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Caroline du Nord</li><li>Grand Londres</li><li>Géorgie (États-Unis)</li><li>Lombardie</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Texas</li><li>Victoria (État)</li><li>État de Rio de Janeiro</li></region><settlement><li>Grenoble</li><li>Londres</li><li>Melbourne</li><li>Milan</li><li>Rio de Janeiro</li><li>Tokyo</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Herceg, Zdenko" sort="Herceg, Zdenko" uniqKey="Herceg Z" first="Zdenko" last="Herceg">Zdenko Herceg</name></region><name sortKey="Ambatipudi, Srikant" sort="Ambatipudi, Srikant" uniqKey="Ambatipudi S" first="Srikant" last="Ambatipudi">Srikant Ambatipudi</name><name sortKey="Degli Esposti, Davide" sort="Degli Esposti, Davide" uniqKey="Degli Esposti D" first="Davide" last="Degli Esposti">Davide Degli Esposti</name><name sortKey="Ghantous, Akram" sort="Ghantous, Akram" uniqKey="Ghantous A" first="Akram" last="Ghantous">Akram Ghantous</name><name sortKey="Hernandez Vargas, Hector" sort="Hernandez Vargas, Hector" uniqKey="Hernandez Vargas H" first="Hector" last="Hernandez-Vargas">Hector Hernandez-Vargas</name><name sortKey="Lepeule, Johanna" sort="Lepeule, Johanna" uniqKey="Lepeule J" first="Johanna" last="Lepeule">Johanna Lepeule</name><name sortKey="Sklias, Athena" sort="Sklias, Athena" uniqKey="Sklias A" first="Athena" last="Sklias">Athena Sklias</name><name sortKey="Wild, Christopher P" sort="Wild, Christopher P" uniqKey="Wild C" first="Christopher P" last="Wild">Christopher P. Wild</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Casati, Lavinia" sort="Casati, Lavinia" uniqKey="Casati L" first="Lavinia" last="Casati">Lavinia Casati</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Duthie, Susan J" sort="Duthie, Susan J" uniqKey="Duthie S" first="Susan J" last="Duthie">Susan J. Duthie</name></noRegion><name sortKey="Rakyan, Vardhman" sort="Rakyan, Vardhman" uniqKey="Rakyan V" first="Vardhman" last="Rakyan">Vardhman Rakyan</name><name sortKey="Teschendorff, Andrew E" sort="Teschendorff, Andrew E" uniqKey="Teschendorff A" first="Andrew E" last="Teschendorff">Andrew E. Teschendorff</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Fry, Rebecca" sort="Fry, Rebecca" uniqKey="Fry R" first="Rebecca" last="Fry">Rebecca Fry</name></region><name sortKey="Issa, Jean Pierre" sort="Issa, Jean Pierre" uniqKey="Issa J" first="Jean-Pierre" last="Issa">Jean-Pierre Issa</name><name sortKey="Kellermayer, Richard" sort="Kellermayer, Richard" uniqKey="Kellermayer R" first="Richard" last="Kellermayer">Richard Kellermayer</name><name sortKey="Koturbash, Igor" sort="Koturbash, Igor" uniqKey="Koturbash I" first="Igor" last="Koturbash">Igor Koturbash</name><name sortKey="Marsit, Carmen J" sort="Marsit, Carmen J" uniqKey="Marsit C" first="Carmen J" last="Marsit">Carmen J. Marsit</name><name sortKey="Taylor, Jack A" sort="Taylor, Jack A" uniqKey="Taylor J" first="Jack A" last="Taylor">Jack A. Taylor</name><name sortKey="Walker, Cheryl Lyn" sort="Walker, Cheryl Lyn" uniqKey="Walker C" first="Cheryl Lyn" last="Walker">Cheryl Lyn Walker</name><name sortKey="Waterland, Robert A" sort="Waterland, Robert A" uniqKey="Waterland R" first="Robert A" last="Waterland">Robert A. Waterland</name><name sortKey="Wiemels, Joe" sort="Wiemels, Joe" uniqKey="Wiemels J" first="Joe" last="Wiemels">Joe Wiemels</name></country><country name="Japon"><noRegion><name sortKey="Kondo, Yukata" sort="Kondo, Yukata" uniqKey="Kondo Y" first="Yukata" last="Kondo">Yukata Kondo</name></noRegion><name sortKey="Ushijima, Toshikazu" sort="Ushijima, Toshikazu" uniqKey="Ushijima T" first="Toshikazu" last="Ushijima">Toshikazu Ushijima</name></country><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="Lima, Sheila C S" sort="Lima, Sheila C S" uniqKey="Lima S" first="Sheila C S" last="Lima">Sheila C S. Lima</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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